![]() ![]() We could identify the following three main phases: (1) learning the initial goal location (2) faster learning after 2 weeks when learning a new goal location and then (3) the ability to express one-session learning, leading to long-term memory effect after 12 weeks. Analyzing performance across sessions as well as on specific trials, we can show simple memory effects as well as multiple effects of previous knowledge of the map accelerating both online learning and performance increases over offline periods when incorporating new information. Here, we developed a new spatial navigation task where food locations are learned in a large, gangway maze to test how mice learn a large spatial map over a longer time period-the HexMaze. Previous knowledge in form of a cognitive map can facilitate knowledge acquisition and will influence how we learn new spatial information. ![]() New information is rarely learned in isolation instead, most of what we experience can be incorporated into or uses previous knowledge networks in some form. ![]()
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March 2023
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